Fenbendazole Fenbendazole’s daily dose can change depending on the patient’s health status and any other medications or chemotherapy they may be on.
Dosage Guideline: Keep in mind: If you are taking other supplements, natural products, nutraceuticals, or non-cancer related drugs along with fenbendazole, or if you’re considering using fenbendazole as a standalone cancer treatment, it is crucial to seek advice from a licensed medical expert. Look for a professional with a positive approach and practical experience in both traditional chemotherapy and alternative cancer treatment, and who has a background in medication reconciliation to avoid unwanted side effects from combining multiple drugs or chemicals.
Storage advice for fenbendazole powder, capsules, and tablets: Keep them under 25 °C and out of direct sunlight.
The Safety, Side Effects, and Breakdown of Fenbendazole in the Body Safety, Genetic Damage Potential, and Cancer Risks It’s challenging to assess the possible health and side effects that fenbendazole, particularly at normal or high doses, might have on humans, since it isn’t a drug typically used in people, and there’s no prior record of human usage. Predicting potential side effects becomes even more difficult when fenbendazole is used with other medications.
Bulk Fenbendazole, on its own, has a very low immediate toxicity when taken orally (as measured in rodent studies). No limit for immediate oral exposure has been defined (it could be that the immediate toxicity threshold is above 5000mg of the substance per kilogram of body weight).
According to human data, it seems that doses up to 500 mg per person did not lead to any negative effects. Likewise, single doses of up to 2,000 mg per person also did not result in any adverse effects.
Based on a series of both in vivo and in vitro genetic damage tests, where the European Medicines Agency was engaged and partly responsible, it was established that fenbendazole does not cause genetic damage.
No evidence of cancer-causing potential was found in a 2-year mouse study.
The above details regarding safety, genetic damage potential, and cancer risks were gathered from.
Possible Side Effects: The possible side effects encompass:
- Vomiting (infrequent)
- Diarrhea (infrequent)
- Jaundice (extremely uncommon)
- Skin itching (extremely uncommon)
- Liver damage (exceptionally rare)
How it Works in the Body: After being absorbed into the body, fenbendazole goes through two stages of transformation – hydroxylation and oxidation.
The first step involves liver enzymes – CYP2J2 and CYP2C19, which help hydroxylate fenbendazole to create a new derivative – hydroxyfenbendazole.
The next step is the oxidation of the sulfide group in the presence of enzyme compounds CYP3A and flavin-containing monooxygenase in the liver, producing a different substance known as oxfendazole. This substance also possesses antitumor and anthelmintic qualities.
Interestingly, these observations suggest that fenbendazole is both a medicine and a prodrug – it stimulates the metabolic production of another active medicine.
Importantly, fenbendazole isn’t entirely converted to its metabolites due to its limited bioavailability. Only a small fraction of it is absorbed through our digestive system. Eventually, fenbendazole, along with hydroxyfenbendazole and oxfendazole, is expelled from the body through feces.
It’s essential for anyone taking any of the medicinal drugs such as tamoxifen, ebastine, amiodarone, astemizole, mesoridazine, apixaban, thioridazine, and cyclosporine in combination with higher dosages of fenbendazole to consult their medical professional for further details on the possible connections between the two, along with potential changes in side-effects and increased risk of toxicity.
This is due to the enzyme CYP2C19 being involved in metabolising the drugs, as well as breaking down fenbendazole. Find out more at: https://fenbenlab.com/shop/